Advancing our understanding of iron and manganese in health and disease
The Seo research group is interested in understanding the cellular and molecular regulation of iron and manganese and how disturbances in their function lead to human diseases.
We are currently focusing on the following projects:
I. Iron metabolism
1. Iron deficiency anemia and Iron overload disorder hemochromatosis: NHLBI R01 Grant
2. Neurodegeneration of Brain Iron Accumulation (NBIA): NBIA Disorder Association "Early-Career Faculty Investigator Grant Award"
II. Manganese metabolism
1. Genetic disorders of manganese metabolism: NIEHS K99/R00 Grant "Pathway to Independence Award"
2. Brain disorders associated with manganese misregulation: NIEHS P30 Pilot Project Grant Award
The Seo research group is interested in understanding the cellular and molecular regulation of iron and manganese and how disturbances in their function lead to human diseases.
We are currently focusing on the following projects:
I. Iron metabolism
1. Iron deficiency anemia and Iron overload disorder hemochromatosis: NHLBI R01 Grant
2. Neurodegeneration of Brain Iron Accumulation (NBIA): NBIA Disorder Association "Early-Career Faculty Investigator Grant Award"
II. Manganese metabolism
1. Genetic disorders of manganese metabolism: NIEHS K99/R00 Grant "Pathway to Independence Award"
2. Brain disorders associated with manganese misregulation: NIEHS P30 Pilot Project Grant Award
Recent News
September 24, 2018
Our new paper on Ferroportin published in FASEB journal. Congrats team!
> Ferroportin disease mutations influence manganese accumulation and cytotoxicity
August 10, 2018
Dr. Seo received an Early-Career Faculty Investigator Grant Award from the Neurodegeneration with Brain Iron Accumulation (NBIA) association.
> NBIA organization awards two grants for BPAN, including the first for an early-career researcher
June 29, 2018
Dr. Seo received a Pilot Project Grant Award from the Michigan Lifestage Environmental Exposures and Disease (M-LEEaD).
May 5, 2018
Dr. Seo presented research at the FASEB conference "Trace element in Medicine and Biology" meeting in Tahoe City, CA.
February 16, 2018
Our new paper on SLC39A8 was accepted for publication published in Scientific Reports. Congrats team!
> Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders.
Highlighted in Mitochondrial Disease News!
> Manganese Deficiency Underlies Mitochondria Defects in Leigh Syndrome, Other Diseases, Study Finds
September 24, 2018
Our new paper on Ferroportin published in FASEB journal. Congrats team!
> Ferroportin disease mutations influence manganese accumulation and cytotoxicity
August 10, 2018
Dr. Seo received an Early-Career Faculty Investigator Grant Award from the Neurodegeneration with Brain Iron Accumulation (NBIA) association.
> NBIA organization awards two grants for BPAN, including the first for an early-career researcher
June 29, 2018
Dr. Seo received a Pilot Project Grant Award from the Michigan Lifestage Environmental Exposures and Disease (M-LEEaD).
May 5, 2018
Dr. Seo presented research at the FASEB conference "Trace element in Medicine and Biology" meeting in Tahoe City, CA.
February 16, 2018
Our new paper on SLC39A8 was accepted for publication published in Scientific Reports. Congrats team!
> Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders.
Highlighted in Mitochondrial Disease News!
> Manganese Deficiency Underlies Mitochondria Defects in Leigh Syndrome, Other Diseases, Study Finds
Recent Articles
Choi EK, Nguyen TT, Iwase S, Seo YA. (2018) Ferroportin disease mutations influence manganese accumulation and cytotoxicity. FASEB journal [Epub ahead of print]
Choi EK, Nguyen TT, Gupta N, Iwase S, and Seo YA. Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. Scientific Reports. 2018 Feb 16;8(1):3163
Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017 May 12;356(6338):608-616.
Seo YA, Kumara R, Wetli H, Wessling-Resnick M. (2016) Regulation of divalent metal transporter-1 by serine phosphorylation. Biochemical Journal, 473(22):4243-4254. PMC5103878
Choi EK, Nguyen TT, Iwase S, Seo YA. (2018) Ferroportin disease mutations influence manganese accumulation and cytotoxicity. FASEB journal [Epub ahead of print]
Choi EK, Nguyen TT, Gupta N, Iwase S, and Seo YA. Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. Scientific Reports. 2018 Feb 16;8(1):3163
Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017 May 12;356(6338):608-616.
Seo YA, Kumara R, Wetli H, Wessling-Resnick M. (2016) Regulation of divalent metal transporter-1 by serine phosphorylation. Biochemical Journal, 473(22):4243-4254. PMC5103878