Advancing our understanding of iron and manganese in health and disease:
The Seo research group is interested in understanding the molecular regulation of iron and manganese and how disturbances in their function lead to human diseases.
We are currently focusing on the following projects:
I. Iron metabolism
1) Iron deficiency anemia and Iron overload disorder hemochromatosis
2) Neurodegeneration of Brain Iron Accumulation (NBIA)
II. Manganese metabolism
1) Genetic disorders of manganese metabolism
2) Brain disorders associated with manganese misregulation
Current funding support to the lab:
NIH/NIEHS K99/R00 Pathway to Independence Award
NIH/NHLBI R01
NBIA Disorder Association Early-Career Faculty Investigator Grant Award
NIH/NIEHS P30 Center Grant Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) Pilot Grant Award
The Seo research group is interested in understanding the molecular regulation of iron and manganese and how disturbances in their function lead to human diseases.
We are currently focusing on the following projects:
I. Iron metabolism
1) Iron deficiency anemia and Iron overload disorder hemochromatosis
2) Neurodegeneration of Brain Iron Accumulation (NBIA)
II. Manganese metabolism
1) Genetic disorders of manganese metabolism
2) Brain disorders associated with manganese misregulation
Current funding support to the lab:
NIH/NIEHS K99/R00 Pathway to Independence Award
NIH/NHLBI R01
NBIA Disorder Association Early-Career Faculty Investigator Grant Award
NIH/NIEHS P30 Center Grant Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) Pilot Grant Award
Recent News
September 24, 2018
Our new paper on Ferroportin published in FASEB journal. Congrats team!
August 10, 2018
Dr. Seo received an Early-Career Faculty Investigator Grant Award from the Neurodegeneration with Brain Iron Accumulation (NBIA) association.
June 29, 2018
Dr. Seo received a Pilot Project Grant Award from the Michigan Lifestage Environmental Exposures and Disease (M-LEEaD).
May 5, 2018
Dr. Seo presented research at the FASEB conference "Trace element in Medicine and Biology" meeting in Tahoe City, CA.
February 16, 2018
Our new paper on SLC39A8 was accepted for publication published in Scientific Reports. Congrats team!
September 24, 2018
Our new paper on Ferroportin published in FASEB journal. Congrats team!
- Choi EK, Nguyen TT, Iwase S, Seo YA. (2018) Ferroportin disease mutations influence manganese accumulation and cytotoxicity. FASEB journal [Pubmed]
August 10, 2018
Dr. Seo received an Early-Career Faculty Investigator Grant Award from the Neurodegeneration with Brain Iron Accumulation (NBIA) association.
- NBIA organization awards two grants for BPAN, including the first for an early-career researcher [NEWS]
June 29, 2018
Dr. Seo received a Pilot Project Grant Award from the Michigan Lifestage Environmental Exposures and Disease (M-LEEaD).
May 5, 2018
Dr. Seo presented research at the FASEB conference "Trace element in Medicine and Biology" meeting in Tahoe City, CA.
February 16, 2018
Our new paper on SLC39A8 was accepted for publication published in Scientific Reports. Congrats team!
Recent Articles
- Choi EK, Nguyen TT, Iwase S, Seo YA. (2018) Ferroportin disease mutations influence manganese accumulation and cytotoxicity. FASEB journal [Pubmed]
- Choi EK, Nguyen TT, Gupta N, Iwase S, Seo YA. (2018) Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. Scientific Reports 16;8(1):3163.[Pubmed]
- Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD. (2017) Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 356(6338):608-616.[Pubmed]
- Seo YA, Kumara R, Wetli H, Wessling-Resnick M. (2016) Regulation of divalent metal transporter-1 by serine phosphorylation. Biochemical Journal, 473(22):4243-4254. PMC5103878 [Pubmed]