Research Interests
Welcome! We are a basic science research laboratory at the University of Michigan. Our interests are in discovering novel and fundamental insights related to iron and manganese biology in physiology and disease.
We are currently focusing on the following projects:
I. Physiological Role of Manganese in Health and Disease
1) New roles of manganese in gut and metabolic disorders.
2) Brain disorders associated with manganese misregulation.
II. Physiological Role of Iron in Health and Disease
1) Brain iron overload disorders & Neurodegeneration of Brain Iron Accumulation (NBIA).
2) Developing new approaches for treatment of iron imbalance disorders.
III. Metalloepigenetics
1) Role of metals in chromatin biology.
2) Impact of metals on neurological disorders.
Welcome! We are a basic science research laboratory at the University of Michigan. Our interests are in discovering novel and fundamental insights related to iron and manganese biology in physiology and disease.
We are currently focusing on the following projects:
I. Physiological Role of Manganese in Health and Disease
1) New roles of manganese in gut and metabolic disorders.
2) Brain disorders associated with manganese misregulation.
II. Physiological Role of Iron in Health and Disease
1) Brain iron overload disorders & Neurodegeneration of Brain Iron Accumulation (NBIA).
2) Developing new approaches for treatment of iron imbalance disorders.
III. Metalloepigenetics
1) Role of metals in chromatin biology.
2) Impact of metals on neurological disorders.
Recent News & Publications
- 2021 Dec, Our grant application on NBIA disorder BPAN has been selected for funding in the 2022 Million Dollar Bike Ride Grant Program from the University of Pennsylvania Orphan Disease Center in partnership with the Team NBIA Disorders and BPAN familes with the NBIA Disorders Association. Congrats team!
- 2021 Dec, Our work on "Defining roles of iron in BPAN" is highlighted in the newletter from NBIA disorders association. [News]
- 2021 Nov, Our manuscript, "A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation" is published in Journal of Neurochemistry. Congrats Luisa and Eunkyeong! [Pubmed]
- 2021 September, Sophie Farr, a master student at UM, joins our lab as a research assistant. She majors biology and applies her lab manager skills to the lab. Welcome, Sophie!
- 2020 December, Our manuscript, "Transcriptome analysis of the cerebellum of mice fed a manganese-deficient diet" published in Frontiers in Genetics. Congrats team! [Pubmed]
- 2020 June, Our collaborative review manuscript, "Heavy Metal Exposure and Alzheimer's Disease and Related Dementias" published in Journal of Alzheimer's Disease. Dr. Seo is a co-first author on this manuscript. Congrats! [Pubmed]
- 2020 April, Our collaborative manuscript, "Cutting Edge: Activation-Induced Iron Flux Controls CD4T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial function" published in Journal of Immunology. Dr. Seo is a co-corresponding author on this manuscript. Congrats team! [Pubmed]
- 2020 Feb, Our manuscript, "Impact of dietary manganese on experimental colitis in mice" published in FASEB journal. Congrats team! [Pubmed]
Thank you to our research funding!
Current
Current
- NIH / NIDDK R01 (PI: Seo)
- NIH / NINDS R21 (PI: Seo)
- NIH / NHLBI R01 (Co-I: Seo)
- Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders Association, "Early-Career Faculty Investigator Grant Award" (PI: Seo)
- 2022 Million Dollar Bike Ride Grant from the University of Pennsylvania Orphan Disease Center (PI: Seo)
- NIH / NIEHS K99/R00 “Pathway to Independence” Award (PI: Seo)
- University of Michigan Michigan Institute for Clinical & Health Research (MICHR) “Pathway to Independence” Award (PI: Seo)
- University of Michigan Center for Gastrointestinal Research Center (PI of the pilot grant: Seo)
- Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) (PI of the pilot grant: Seo)
- University of Michigan MCUBED (Co-PI of the pilot grant: Seo)
